Is Perlane or Juvederm better for filling nasolabial folds?

Both should work well for smile lines. Perlane is a thicker substance than the Juvederm XC (Juvederm XC Plus is available for those who want thicker Juvederm) and it works well for patients with deeper smile lines. Perlane uses a wider bore needle and carries a slightly higher risk of bleeding and bruising.